| ncRNA name | HIF-1α siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell line WERI-RB1 |
| Methods | siRNA transfection, semi-quantitative RT-PCR, Western blot, flow cytometry, MTT assay |
| Expression pattern | associated |
| Functional description | The knockdown of HIF-1α under hypoxic conditions downregulated VEGF, GLUT1, and Survivin mRNA. It also inhibited proliferation, promoted apoptosis, induced the G0/G1 phase cell cycle arrest, and reduced the adhesion and invasion of WERI-Rb-1 cells. |
| PubMed ID | 24795051 |
| Year | 2014 |
| Title | Knockdown of hypoxia-inducible factor-1 alpha reduces proliferation, induces apoptosis and attenuates the aggressive phenotype of retinoblastoma WERI-Rb-1 cells under hypoxic conditions. |
| Drug-related ncRNA | NO |
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